Uppsala University's Pioneering Mouse Model Set to Revolutionize Bladder Cancer Research
Scientists at Uppsala University have developed a pioneering mouse model to study human bladder cancer progression and immune response. Published in PLOS ONE, this model could revolutionise our understanding of the disease and its treatment.
The innovative model, created by Prof. Dr. Martin Eilers' research group, mimics human bladder cancer development by carrying specific oncogenes and exhibiting a high incidence of harmful mutations. Notably, it features a fully functional human-like immune system, allowing tumours to grow in the correct site and for the same reasons as in humans.
This model enables the study of tumour development in both male and female mice, providing valuable insights into gender-specific responses to various treatments. Single-cell sequencing and proteomic profiling of blood and urine samples have been employed to track gene expression changes and tumour progression in the model.
Funded by the Swedish Cancer Society, the Swedish Society for Medical Research, and the European Social Fund, this research has the potential to enhance our understanding of immune cell infiltration and bladder cancer progression. The distinct gender differences observed in early-stage bladder cancer and immunotherapy response could pave the way for tailored, gender-specific treatment strategies.
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