Researchers Discover 'First Responder' Cells in Pancreas Linked to Diabetes
An international research team, led by Prof. Dr. rer. medic. Ina Danquah at the University of Bonn's Center for Development Research (ZEF) and the Heidelberg Institute of Global Health (HIGH), is making strides in understanding the origins of diabetes and other metabolic diseases. Their latest findings, conducted in collaboration with the Technical University of Dresden, offer promising insights into potential new treatment methods.
The team, also led by Prof. Nikolay Ninov at the Center for Regenerative Therapies Dresden (CRTD), has discovered a group of 'First Watch' cells in the pancreas. These cells, more sensitive to blood sugar levels than others, act as a control center, regulating the activity of other beta cells. Intriguingly, these First Watch cells produce a key enzyme that converts inactive vitamin B6 into its active form, which they may use to regulate other beta cells.
To study this, the researchers used young zebrafish with transparent skin. This allowed them to observe the pancreas' function, as it shares similarities with the human pancreas. The team suspects that low vitamin B6 levels may be linked to the occurrence of metabolic diseases and type 2 diabetes. Their findings could pave the way for new treatment methods, targeting these First Watch cells and vitamin B6 activity.
The international research team's discovery of First Watch cells and their role in vitamin B6 activation could significantly impact our understanding of diabetes and other metabolic diseases. Further investigation is needed to confirm these findings and develop potential new treatments targeting these cells and vitamin B6 levels.
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