Neuroblastoma: Understanding the Cancer Affecting Infants
Neuroblastoma, a cancer that affects immature cells of the sympathetic nervous system, is most common among infants. Approximately 700 new cases are diagnosed annually in the United States. Symptoms include lumps, bulging eyes, abdominal swelling, bone pain, weakness, and skin changes. It develops as a solid tumor, often in the adrenal gland, pelvis, abdomen, neck, or chest. Most cases aren't inherited, but about 1-2% are. Treatment depends on the child's age and the cancer's stage, with significant progress made in immunotherapy for relapse patients.
Neuroblastoma is diagnosed through blood and urine tests, bone marrow biopsy, imaging scans, and other tests. It has four stages, with stage 4 being the most advanced and severe. Treatment options include surgery, chemotherapy, radiation therapy, and targeted immunotherapy. The outlook varies, with five-year survival rates ranging from about 40 to 95 percent. If it progresses, it can spread to bones, lymph nodes, and skin. Most cases aren't inherited, but about 1-2% are, following an autosomal dominant pattern.
Neuroblastoma is a serious condition that requires prompt medical attention. With proper treatment, many children can overcome this disease. Recent advancements in immunotherapy have significantly improved prognosis for relapse patients. As with any cancer, early detection and appropriate treatment are crucial for the best possible outcome.
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