Interactions of Motegrity: Other drugs, alcohol, and various substances
In the world of healthcare, it's crucial to be aware of potential interactions between medications and other substances. This article focuses on Motegrity, a brand-name oral tablet prescribed for chronic idiopathic constipation in adults.
Motegrity, also known as prucalopride, works by increasing muscular contractions in your intestine to help with bowel movements. However, it's essential to keep your doctor and pharmacist informed about all medications, supplements, herbs, and vitamins you take, as they may interact with Motegrity.
One medication to be mindful of is Fosfomycin, an antibiotic prescribed to treat some urinary tract infections (UTIs) caused by bacteria. Taking Motegrity with Fosfomycin could make this antibiotic less effective. If you're prescribed Fosfomycin along with Motegrity, your doctor may recommend taking your Fosfomycin dose at a different time of day than your Motegrity dose.
Common interactions involving Motegrity include potential reduced effectiveness when taken with certain medications like diphenhydramine (found in Advil PM) and ipratropium. These anticholinergic agents may diminish Motegrity's effect in treating chronic constipation. Other medications such as amitriptyline, atorvastatin, and baclofen may also have interaction risks, so it's important to inform your doctor about all supplements and drugs you are taking before starting Motegrity.
However, there are no specific reports of vitamin interactions with Motegrity, nor are there any known interactions between Motegrity and alcohol or vaccines. Yet, your doctor may advise you to avoid or limit alcohol consumption during Motegrity treatment due to potential worsening of side effects.
It's also important to note that certain medical conditions and factors may increase the risk of interactions with Motegrity. These include allergic reactions, blockage, tear, or serious inflammation in the intestine, history of depression or suicidal thoughts, kidney problems, breastfeeding, pregnancy, and a history of suicidal thoughts or depression. Having a perforation (tear) in the wall of your intestine or a blockage in your intestine caused by a problem with the structure or function of your intestine could prevent your doctor from prescribing Motegrity.
When it comes to herbal interactions, there are no specific reports of herbal interactions with Motegrity. However, since Motegrity affects gastrointestinal motility, it's generally advisable to discuss diet and any herbal supplements with your healthcare provider while using this medication.
Lastly, it's always important to read the Motegrity label and other information that may come with the drug, as it may contain details about interactions. If you have severe inflammatory bowel disease (IBD), your doctor will likely not prescribe Motegrity. If you have had an allergic reaction to Motegrity or any of its ingredients, your doctor will likely not prescribe Motegrity.
In summary, the most common concerns are drug interactions that may reduce Motegrity's effectiveness, especially with anticholinergic agents like diphenhydramine and ipratropium. Monitoring and consultation with a physician are recommended when combining Motegrity with other medications or supplements. By taking these precautions, you can help prevent interactions with Motegrity and ensure the best possible treatment for your chronic constipation.
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