Angelman Syndrome Patients' Distinctive Laughter Linked to Brain Structure
Angelman syndrome patients are known for their distinctive laughter, often described as a key part of their behavioral profile. A recent review of 64 studies found that 60 of them mentioned patients with this genetic disorder being happy or laughing frequently. Researchers have discovered that several brain areas, including the frontal cortex, nucleus accumbens, and supplementary motor area, contribute to laughter in Angelman syndrome patients. These areas, primarily located in the left hemisphere, are also involved in most humor-related brain activities. The increased laughter in Angelman syndrome patients is not related to seizures, as previously thought. Instead, it may be linked to differences in brain structure, such as a smaller nucleus accumbens and lower nerve fiber connections. This laughter can sometimes be inappropriate or unrelated to context. Interestingly, laughter in Angelman syndrome patients may decrease with age or due to health issues like gastroesophageal reflux disease. However, it's important to note that this laughter is not necessarily a sign of happiness. It may be connected to neurological factors influencing the expression of emotion. Angelman syndrome patients' frequent laughter is a characteristic feature of the disorder, influenced by brain structure and function. While it's often perceived as a sign of happiness, it may also be linked to neurological factors. The Angelman Syndrome News website provides information and updates about the disease, but it does not offer medical advice.
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